I think I read somewhere that the amount of Tysabri given during a single infusion is the same for everyone regardless of size - is that true?
I remember it was suggested that of patients that meet the stated PML risk factors (JCV+, been on the drug >2 years, etc) - that it was typically smaller individuals that would get PML. I don't know if this is accurate either, but if the drug dose was the same for everyone it might follow that a smaller individual would have a proportionally higher concentration of the drug in their system.
Anyway my reason for asking is that I've been encouraged to see the posts and studies that have shown a significant decrease in PML risk without much loss of efficacy for patients on an extended (8 week) dosage schedule. I was wondering if it is known (or is planned to study) whether a smaller dosage given on the 4-week schedule would similarly decrease risk? It seems like it would be potentially less taxing on a patient's system to have a smaller dose at more frequent intervals. (This is just my own logic and thought stream, no foundation in medicine at all).
I remember it was suggested that of patients that meet the stated PML risk factors (JCV+, been on the drug >2 years, etc) - that it was typically smaller individuals that would get PML. I don't know if this is accurate either, but if the drug dose was the same for everyone it might follow that a smaller individual would have a proportionally higher concentration of the drug in their system.
Anyway my reason for asking is that I've been encouraged to see the posts and studies that have shown a significant decrease in PML risk without much loss of efficacy for patients on an extended (8 week) dosage schedule. I was wondering if it is known (or is planned to study) whether a smaller dosage given on the 4-week schedule would similarly decrease risk? It seems like it would be potentially less taxing on a patient's system to have a smaller dose at more frequent intervals. (This is just my own logic and thought stream, no foundation in medicine at all).
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