Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
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Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
0
16 hours ago
0
Diseases, Conditions, Syndromes
Neuroscience
Editors' notes
Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
by Brigham and Women's Hospital
Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
Credit: Journal of Neurology (2023). DOI: 10.1007/s00415-023-11907-8
Between 30% and 50% of people living with multiple sclerosis (MS) will experience memory problems, but the cause is uncertain. Brain lesions are the hallmark imaging sign used to diagnose MS and are often associated with memory dysfunction. However, increased MS brain lesions are not specific to memory problems, and are also associated with fatigue, walking difficulty and other common MS symptoms. Previous studies that attempted to align the anatomy of lesions associated with memory problems in MS led to conflicting results.
Researchers from Brigham and Women's Hospital have conducted a study to figure out which MS lesion locations are associated with memory issues. The team, led by Isaiah Kletenik, MD, analyzed imaging and cognitive data from 431 people with MS enrolled in the Comprehensive Longitudinal Investigation of MS at Brigham and Women's Hospital, or CLIMB study. Researchers mapped white matter lesion locations from each person and tested associations between memory dysfunction and a memory circuit previously derived from strokes causing memory problems.
They found that MS lesions that were associated with memory problems intersected with this memory circuit centered on the hippocampus. The researchers also analyzed the MS lesion locations compared to large functional and structural brain atlases to identify unique MS memory circuits.
The study is published in the Journal of Neurology.
Full article:
https://medicalxpress.com/news/2023-...-multiple.html
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Autism Spectrum Disorders
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Diseases, Conditions, Syndromes
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Gastroenterology
Genetics
Gerontology & Geriatrics
HIV & AIDS
Health
Health Informatics
Immunology
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Medical Economics
Medical Research
Medications
Neuroscience
Obstetrics & Gynaecology
Oncology & Cancer
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Overweight & Obesity
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Vaccination
Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
0
16 hours ago
0
Diseases, Conditions, Syndromes
Neuroscience
Editors' notes
Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
by Brigham and Women's Hospital
Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit
Credit: Journal of Neurology (2023). DOI: 10.1007/s00415-023-11907-8
Between 30% and 50% of people living with multiple sclerosis (MS) will experience memory problems, but the cause is uncertain. Brain lesions are the hallmark imaging sign used to diagnose MS and are often associated with memory dysfunction. However, increased MS brain lesions are not specific to memory problems, and are also associated with fatigue, walking difficulty and other common MS symptoms. Previous studies that attempted to align the anatomy of lesions associated with memory problems in MS led to conflicting results.
Researchers from Brigham and Women's Hospital have conducted a study to figure out which MS lesion locations are associated with memory issues. The team, led by Isaiah Kletenik, MD, analyzed imaging and cognitive data from 431 people with MS enrolled in the Comprehensive Longitudinal Investigation of MS at Brigham and Women's Hospital, or CLIMB study. Researchers mapped white matter lesion locations from each person and tested associations between memory dysfunction and a memory circuit previously derived from strokes causing memory problems.
They found that MS lesions that were associated with memory problems intersected with this memory circuit centered on the hippocampus. The researchers also analyzed the MS lesion locations compared to large functional and structural brain atlases to identify unique MS memory circuits.
The study is published in the Journal of Neurology.
Full article:
https://medicalxpress.com/news/2023-...-multiple.html