Multiple sclerosis (MS) is a debilitating autoimmune disease that can lead to paralysis. We demonstrate that an antigen-specific microparticle treatment can reverse hind limb paralysis when administered in advanced experimental autoimmune encephalomyelitis (EAE).
Single-cell RNA sequencing and flow cytometry analysis provide evidence that the treatment acts by diminishing antigen (Ag) presentation in antigen presenting cells (APCs), including B cells in the central nervous system (CNS) and the draining lymph nodes. Thus, the antigen-specific dual-sized microparticle treatment is a promising therapy even in advanced EAE and potentially MS.
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https://www.pnas.org/doi/10.1073/pnas.2205417119
Single-cell RNA sequencing and flow cytometry analysis provide evidence that the treatment acts by diminishing antigen (Ag) presentation in antigen presenting cells (APCs), including B cells in the central nervous system (CNS) and the draining lymph nodes. Thus, the antigen-specific dual-sized microparticle treatment is a promising therapy even in advanced EAE and potentially MS.
There's a pay wall preventing full access to the article.
https://www.pnas.org/doi/10.1073/pnas.2205417119