Is there any activity to regenerate myelin ?

[JerryD]

I have seen some discussion ,but very little, about regenerating the myelin sheath on the nerves of MSers ! What is going on with this ? Are there any clinical trials for a therapeutic taking place ?

[Boudreaux]

There is a study that shows metformin regenerates myelin in mice. Not sure how thats gonna translate into humans. Also I think I may have read something about fasting acting the same way.

[Seasha]

Hi Jerry- Here's more information about Metformin from the MSSociety in England. https://www.mssociety.org.uk/researc...repair-in-rats

I'm not holding my breath for a solution in the near future, but hoping for something in my lifetime. If not then, for others along the way.
But with the newer, stronger more efficient drugs for RRMS, maybe fewer people will need regenerate myelin repair!

[KoKo]

Hello JerryD ~

I found this info - Remyelination News and Research

Remyelination News, Research (news-medical.net)

It seems that there is quite a bit of research activity for myelin repair, but I haven't found much in the human Clinical Trial stages yet.

It appears that most are in the mouse model stage.

[KoKo]

Hot off the press! Phase 1 Clinical Trial

Pipeline Testing PIPE-307 Remyelinating Compound in Healthy Volunteers

Pipeline Therapeutics Initiates Phase 1 Clinical Trial of PIPE-307 | Business Wire

[Boudreaux]

Thanks Koko.

[JerryD]

Hi everyone,
About 1 year ago, I started this thread to discuss and investigate the state of myelin regeneration for us, MSers ! This week I saw a news story that says the drug Pipe307 has completed phase 1 clinical trials, successfully ! I guess, if all goes well, we may see this drug on the market, in 20 years or so ! From my lips to God's ears !

[REG53]

Too late for me.

[oceanpride]

Too late for me.

I know that feeling.
But I would still try it.

[beethoven13]

Remyelination is happening! The Clene Nano trial needs more volunteers with RRMS/PPMS to participate. The trial is at The Univ. of Texas Southwestern in Dallas. Info on study and contact details are here: https://clinicaltrials.gov/ct2/show/NCT03993171