Originally posted by REG53
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A little background on the dosing of temelimab.
The Phase 2b trial (NCT02782858) was dosed at 6, 12, and 15 mg per kilogram of weight. The highest dose showed efficacy. Next, a Phase 1 safety trial was organized using a dose of 35, 60, 85, or 110mg per kg of weight in 24 healthy volunteers to see if the higher doses were safe. Happily, there were no adverse events at the higher doses.
Next, there will be human trials to establish what dose is most effective to halt MS and allow remyelination to occur as a natural process.
If newly diagnosed with MS, I believe I would check the internet daily to make sure I did not miss an opportunity for the next temelimab trial.
Of course, this treatment is very, very early in development, however, in my opinion, temelimab may prove to be the closest thing to a cure for MS depending on the definition of cure. My definition of a cure for MS is the halting of progression and remyelination of damaged nerves.
Only living nerves can remyelinate; dead ones cannot. Once dead, nerves are dead forever. Nerves die over time from becoming demyelinated. However, damaged nerves can and do repair myelin if the mechanism blocking remyelination is suppressed and that is what temelimab demonstrated in small studies… it suppressed mechanisms blocking remyelination which allowed natural processes to form myelin around nerves.
Yes, it is very early in development but temelimab is looking really good, IMO.
https://www.neurologylive.com/clinic...erosis-phase-1
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