AB Science‘s masitinib significantly slowed disability progression in people with primary progressive multiple sclerosis (PPMS) and non-active secondary progressive MS (SPMS) at a lower dose of 4.5 mg/kg a day, top-line results from a Phase 2b/3 clinical trial show.
Masitinib, formerly known as AB1010, is an oral therapy that inhibits the activity of cells in the innate immune system, specifically mast cells, microglia, and macrophages. In doing so, the therapy is expected to limit the inflammatory processes that cause damage to the nervous system in MS.
It may also have applications in other conditions, including other neurological diseases and certain cancers.
“People with primary progressive (PPMS) and non-active secondary progressive (nSPMS) forms of multiple sclerosis account for half of all MS patients,” Patrick Vermersch, PhD, a professor at University of Lille in France and a trial investigator, said in an AB Science press release.
PPMS is estimated to affect about 15% of all MS patients, while non-active SPMS affects about 30% to 35%.
“While numerous treatments based on targeting of B-cells and T-cells of the adaptive immune system are available for patients with relapsing forms of MS, these strategies have failed or had inconclusive results in PPMS and nSPMS. Consequently, there remains a very high medical need for people” with progressive MS forms, Vermersch added.
https://multiplesclerosisnewstoday.c...ple-sclerosis/
Masitinib, formerly known as AB1010, is an oral therapy that inhibits the activity of cells in the innate immune system, specifically mast cells, microglia, and macrophages. In doing so, the therapy is expected to limit the inflammatory processes that cause damage to the nervous system in MS.
It may also have applications in other conditions, including other neurological diseases and certain cancers.
“People with primary progressive (PPMS) and non-active secondary progressive (nSPMS) forms of multiple sclerosis account for half of all MS patients,” Patrick Vermersch, PhD, a professor at University of Lille in France and a trial investigator, said in an AB Science press release.
PPMS is estimated to affect about 15% of all MS patients, while non-active SPMS affects about 30% to 35%.
“While numerous treatments based on targeting of B-cells and T-cells of the adaptive immune system are available for patients with relapsing forms of MS, these strategies have failed or had inconclusive results in PPMS and nSPMS. Consequently, there remains a very high medical need for people” with progressive MS forms, Vermersch added.
https://multiplesclerosisnewstoday.c...ple-sclerosis/
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