The first participant has been dosed in the Phase 2 REPAIR-MS clinical trial examining the effects of CNM-Au8, Clene Nanomedicine‘s investigational remyelinating therapy, on brain metabolism in people with multiple sclerosis (MS), the company announced.
CNM-Au8 is a solution of gold nanoparticles with a particular crystal structure that can help facilitate certain chemical reactions within cells. It can also promote the activation of oligodendrocytes, the cells responsible for producing myelin.
Preclinical data in animal models of MS suggested that CNM-Au8 is able to induce remyelination, and preliminary clinical studies in healthy volunteers indicated the medication has a good safety profile.
REPAIR-MS (NCT03993171) is an open-label Phase 2 trial sponsored by Clene to assess the safety, pharmacokinetic and pharmacodynamic properties, and metabolic effects of CNM-Au8 in 24 adults with relapsing-remitting MS (RRMS) diagnosed in the past 15 years.
Full story available here:
https://multiplesclerosisnewstoday.c...peutic-cnm-au8
CNM-Au8 is a solution of gold nanoparticles with a particular crystal structure that can help facilitate certain chemical reactions within cells. It can also promote the activation of oligodendrocytes, the cells responsible for producing myelin.
Preclinical data in animal models of MS suggested that CNM-Au8 is able to induce remyelination, and preliminary clinical studies in healthy volunteers indicated the medication has a good safety profile.
REPAIR-MS (NCT03993171) is an open-label Phase 2 trial sponsored by Clene to assess the safety, pharmacokinetic and pharmacodynamic properties, and metabolic effects of CNM-Au8 in 24 adults with relapsing-remitting MS (RRMS) diagnosed in the past 15 years.
Full story available here:
https://multiplesclerosisnewstoday.c...peutic-cnm-au8
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