A large retrospective study suggests that a magnetic resonance imaging (MRI) marker — called “brain atrophied T2 lesion volume” — could help predict the timing of multiple sclerosis (MS) progression.
According to the study, this marker was the only MRI parameter capable of predicting disease progression, compared with other markers such as changes in number and volume of lesions, or whole brain atrophy (shrinkage).
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To study whether this marker is in fact a good indicator of MS progression, researchers at the Jacobs School of Medicine and Biomedical Sciences, at the University of Buffalo, collected data on a large group of patients during a five-year follow-up period.
Overall, researchers analyzed MRI scans from 1,314 MS patients (mean age of 46 years), 124 patients with clinically isolated syndrome (CIS; mean age of 39 years), and 147 healthy controls (mean age of 42 years).
Results showed that 336 patients with CIS or MS showed disease progression, and 67 converted from CIS or relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS).
Patients with disease progression accumulated a greater amount of atrophied T2 lesion volume per year during the study. When researchers compared this MRI marker between patients with or without disease progression, they observed that patients with disease progression had on average 34.4 cubic millimeters more of atrophied T2 lesion volume, than those whose disease didn’t progress.
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“This study corroborates initial reports from our group regarding using atrophied lesion volume as a potential MRI marker of disease progression in a large, population-based cohort of MS patients followed in clinical routine,” said Zivadinov.
Overall, the team said, “in this large population-based cohort study, we showed that atrophied brain T2 lesion volume represents a viable predictive MRI marker of the development of disability progression and conversion to secondary progressive multiple sclerosis disease course.”
https://multiplesclerosisnewstoday.c...y-progression/
According to the study, this marker was the only MRI parameter capable of predicting disease progression, compared with other markers such as changes in number and volume of lesions, or whole brain atrophy (shrinkage).
...
To study whether this marker is in fact a good indicator of MS progression, researchers at the Jacobs School of Medicine and Biomedical Sciences, at the University of Buffalo, collected data on a large group of patients during a five-year follow-up period.
Overall, researchers analyzed MRI scans from 1,314 MS patients (mean age of 46 years), 124 patients with clinically isolated syndrome (CIS; mean age of 39 years), and 147 healthy controls (mean age of 42 years).
Results showed that 336 patients with CIS or MS showed disease progression, and 67 converted from CIS or relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS).
Patients with disease progression accumulated a greater amount of atrophied T2 lesion volume per year during the study. When researchers compared this MRI marker between patients with or without disease progression, they observed that patients with disease progression had on average 34.4 cubic millimeters more of atrophied T2 lesion volume, than those whose disease didn’t progress.
...
“This study corroborates initial reports from our group regarding using atrophied lesion volume as a potential MRI marker of disease progression in a large, population-based cohort of MS patients followed in clinical routine,” said Zivadinov.
Overall, the team said, “in this large population-based cohort study, we showed that atrophied brain T2 lesion volume represents a viable predictive MRI marker of the development of disability progression and conversion to secondary progressive multiple sclerosis disease course.”
https://multiplesclerosisnewstoday.c...y-progression/
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