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    Nanocurcumin

    Nanocurcumin

    The restoration of dysregulated Th17 cells using nanocurcumin demonstrated by the study below will prove massively beneficial to people with MS, IMO. Truly, virtually anyone with MS whether it is RRMS, SPMS, or PPMS could benefit from better functioning Th17 cells, IMO.


    Important! The curcumin used was nanocurcumin... that is, very small particles which are highly absorbable. There are only a very few suppliers nanocurcumin on Amazon at present. IMO, that is bound to change over time because nanocurcumin cancer studies demonstrate great promise in detroying cancer cells.

    Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis.

    https://www.ncbi.nlm.nih.gov/pubmed/29852475#

    Dolati S, Ahmadi M, Rikhtegar R, Babaloo Z, Ayromlou H, Aghebati-Maleki L, Nouri M, Yousefi M.


    BACKGROUND:

    MS is a chronic inflammatory disease that causes to brain inflammation and Th17 cells are considered to be important in multiple sclerosis pathogenesis. In the current study, we aimed to identify nanocurcumin effects on Th17 cells frequency, cytokines secretion, and expression of transcription factor of patients with relapsing-remitting multiple sclerosis (RRMS).


    METHODS:

    In this study we investigated frequency of Th17 lymphocytes; the expression of transcription factor, associated cytokines and the concentration of them in 35 healthy controls, and from 25 patients at baseline and after 6 months of nanocurcumin treatment and also from 25 patients whose received placebo by flowcytometry, real-time PCR and ELISA, respectively.

    RESULTS:

    Our analysis revealed that the proportions of Th17 were increased dramatically, along with increases in the levels of IL-17A, IL-23, and RORγt expression in MS patients in compared with healthy control group. Post-treatment evaluation of the nanocurcumin group revealed a significant decrease in Th17 associated parameters such as Th17 frequency (p = 0.029), expression levels of RORγt (p < 0.0001) and IL-17 (p = 0.0044) and also secretion level of IL-17 (p = 0.0011), but IL-23 mRNA expression levels and IL-23 concentration were not influenced by nanocurcumin. However, in the placebo group there is no significant changes in these factors.

    CONCLUSION:

    Our study suggests that the increase in proportion of Th17 cells might contribute to the pathogenesis of RRMS. The results of the current work indicated that nanocurcumin is able to restore the dysregulated of Th17 cells in MS patients.

    #2
    Completely not MS-related, but a lot of symptoms are similar...

    https://vitalrecord.tamhsc.edu/curcu...f-war-illness/

    Comment


      #3
      Originally posted by Marco View Post
      Completely not MS-related, but a lot of symptoms are similar...

      https://vitalrecord.tamhsc.edu/curcu...f-war-illness/

      Thank you for the link to a supporting article, Marco. Curcumin seems quite beneficial. The article does mention curcumin helped alleviate brain inflammation, which is a problem in MS, also. I'll quote that portion below keeping in mind the MS study used nanocurcumin...


      “We were very encouraged by the results,” Shetty said. “We found the individuals with GWI treated with curcumin for 30 days showed better cognitive function and mood than the control group did.”

      These improvements were more than just functional. “Curcumin treatment helped in alleviating the brain inflammation seen in GWI,” said Maheedhar Kodali, PhD, a postdoctoral fellow and the first author of this study. “It also enhanced the expression of genes that encode for antioxidants and normalized the expression of genes related to the function of mitochondria in the hippocampus.”

      “Particularly, the ability of curcumin to reduce the occurrence of activated microglia, a sign of eased brain inflammation, is remarkable,” Shetty added.

      The compound also seemed to enhance the formation of new neurons in the hippocampus, the part of the brain responsible for learning, memory and mood and the region where new neurons are added throughout life in normal individuals.

      “This study showed that curcumin can mediate anti-inflammatory, antioxidant, neurogenic and cognitive and mood enhancing effects in a condition such as GWI,” said Shetty. This corresponds well with the findings of a separate study in humans from the University of California Los Angeles, which recently showed curcumin improved the cognitive function of older adults by 28 percent."

      Comment


        #4
        I found the following article which referenced using 80mg daily.

        https://clinicaltrials.gov/ct2/show/NCT03150966

        Comment


          #5
          Thank you, Cindy!

          80mg of nanocurcumin is a not a large amount so cost should not prevent many who wished from trying. A bottle of 60 count 250mg capsules of Nanocurcumin costs $29.99 on Amazon. Of course, these caps can be opened and 1/3 (about 80mg) sprinkled on food if so desired. The taste is fine, btw.

          I have studied MS for decades and it is so rare to come across something this safe, this effective, and this inexpensive! IMO, there are at least 3 safe things which would likely benefit the majority of people with MS... Vitamin D, LDN, and nanocurcumin.

          Of course, nanocurcumin is relatively new but we may learn more from future studies, I hope. However, we may never see a large Phase 3 trial because there is no financial incentive for a pharma company to study something they cannot monetize by patenting it.

          Thank you, again! You are so helpful!

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