Researchers recruited 21 patients with MS and 25 healthy controls to undergo diffusion MRI scans.
They used the AxCaliber protocol, which allows for the measurement of axon diameter distribution, focused on sagittal sections of the corpus callosum (CC).
The series of diffusion images revealed significant differences in axonal morphology at all callosal sections between the 2 groups (r < .035). Compared with healthy controls, patients with MS had a 10% decrease in axon diameter in the genu, 20% decrease in the body, and 15% decrease in the splenium.
The results suggest that differences in axon diameter distribution can be detected using this method and may be suggestive of MS pathophysiology.
http://www.neurologyadvisor.com/ectr...rticle/522666/
They used the AxCaliber protocol, which allows for the measurement of axon diameter distribution, focused on sagittal sections of the corpus callosum (CC).
The series of diffusion images revealed significant differences in axonal morphology at all callosal sections between the 2 groups (r < .035). Compared with healthy controls, patients with MS had a 10% decrease in axon diameter in the genu, 20% decrease in the body, and 15% decrease in the splenium.
The results suggest that differences in axon diameter distribution can be detected using this method and may be suggestive of MS pathophysiology.
http://www.neurologyadvisor.com/ectr...rticle/522666/