Originally posted by daisy.girl
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the rebound effect & IRIS.
the rebound affect happens to 40% of people when stopping TYsabri- it causes a persons ms to be more active than when they started tysasbri, makes it important to get on a different med as soon as possible when stopping ty.
IRIS i think does require pml i think.
IRIS happens when the immune system can enter the brain again after tysabri had prevented the immune system from getting into the brain.
the immune system gets back into the brain and finds the jc virus there & start attacking the virus, but while attacking the virus some brain tissue is also damaged.
there is going to be some damage to the brain when the immune system starts fighting the JC virus. the damage can be minor, moderate, & severe to death.
the europeans were the first to keep a patient alive through IRIS, they just put people in life support while the immune system was attacking the jc virus. people then survived the virus attack, some had mild or moderate disabilities after getting off life support,some had severe disability including being bedridden, with loss of cognitive skills..
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