Previous immunisations still good after starting ocrevus?

[Chirpy]

Hi team, i know ocrevus diminishes the response to new immunisations, but I'm wondering if anyone has heard anything about it diminishing the effectiveness of immunisations done before starting ocrevus?
its of general interest.. but also, I just stood on a dirty nail, so wondering if my 3 year old tetanus immunisation is still good! (The general advice is if its been more than 5 years since your last shot and you stood on a dirty nail you should get a booster.. but.. wondering if ocrevus might change that!) Been on ocrelizumab for 1 year, was on natalizumab before that 😊

[Mamabug]

Important question. I don't know the answer.

Have you called your neuro's office to ask them? They might have advice / feedback.

[oceanpride]

I’ve wondered the same thing.
Have been on Ocrevus three years. I have had lots of cuts , scrapes , pokes , and scratches and everything has so far healed up just fine. Good luck.

[Chirpy]

Thanks for your replies :-)
I will definately be asking my medical proffessionals! Have to wait until Monday though :-/
The whole vaccine response reduction is a little unsettling! But I'm not as worried about PML as I was on Tysabri - so its a bit of a win some lose some balance 🤣 (they are both win though! I've had no relapses on either!)

[Kimba22]

Hi Chirpy,

The only study I'm aware of regarding the effectiveness of vaccines is the VELOCE study, which showed a lowered response to vaccines after starting Ocrevus treatment. https://n.neurology.org/content/95/14/e1999

So you should still be good with your tetanus vaccine, especially since you had it before starting treatment with Ocrevus.

The whole vaccine response reduction is a little unsettling! But I'm not as worried about PML as I was on Tysabri - so its a bit of a win some lose some balance 🤣 (they are both win though! I've had no relapses on either!)

Yeah, but good to hear it's working for you.

Best wishes