No Evidence of Progression More Likely Among PPMS Patients on Ocrevus
Ocrevus (ocrelizumab) increased the proportion of patients with no evidence of progression (NEP) in the recently concluded ORATORIO Phase 3 clinical trial in patients with primary progressive multiple sclerosis (PPMS).
NEP was defined as having no disability progression as measured by the Expanded Disability Status Scale (EDSS) at 12 weeks, and no confirmed progression of 20 percent or more on the timed 25-foot walk test and on the 9-hole peg test. These tests cover the patient’s overall disability, including both arm function and ambulation. Patients continued evaluations until the end of the study or until researchers recorded a pre-specified number of progressions.
At 120 weeks, 42.7 percent of Ocrevus-treated patients reached NEP, compared to only 29.1 percent among those receiving placebo. The difference represents a 47 percent relative increase in the Ocrevus group.
https://multiplesclerosisnewstoday.com/2017/02/23/actrims2017-no-evidence-of-progression-among-large-part-of-ppms-patients-on-ocrevus-reason-for-optimism/
Ocrevus (ocrelizumab) increased the proportion of patients with no evidence of progression (NEP) in the recently concluded ORATORIO Phase 3 clinical trial in patients with primary progressive multiple sclerosis (PPMS).
NEP was defined as having no disability progression as measured by the Expanded Disability Status Scale (EDSS) at 12 weeks, and no confirmed progression of 20 percent or more on the timed 25-foot walk test and on the 9-hole peg test. These tests cover the patient’s overall disability, including both arm function and ambulation. Patients continued evaluations until the end of the study or until researchers recorded a pre-specified number of progressions.
At 120 weeks, 42.7 percent of Ocrevus-treated patients reached NEP, compared to only 29.1 percent among those receiving placebo. The difference represents a 47 percent relative increase in the Ocrevus group.
https://multiplesclerosisnewstoday.com/2017/02/23/actrims2017-no-evidence-of-progression-among-large-part-of-ppms-patients-on-ocrevus-reason-for-optimism/
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