Announcement

Collapse
No announcement yet.

Lemtrada Mode of Action Question.

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    Lemtrada Mode of Action Question.

    Hello,
    After viewing a clip on youtube from MSWORLDinc titled "New Updates about Lemtrada (Alemtuzumab)"
    https://www.youtube.com/watch?v=iDoleZkD5jo
    I am wondering
    "In what way are the cells that come back different? ( mentioned at the 2 minute 57 second mark) I understand that the cells which grow back after treatment are thought to not cause damage to the nerves but what makes these cells different to the other cells? What does Lemtrada do to make the new cells "behave" and not attack myelin. Thanks

    #2
    Originally posted by lukeloop View Post
    Hello,
    After viewing a clip on youtube from MSWORLDinc titled "New Updates about Lemtrada (Alemtuzumab)"
    https://www.youtube.com/watch?v=iDoleZkD5jo
    I am wondering
    "In what way are the cells that come back different? ( mentioned at the 2 minute 57 second mark) I understand that the cells which grow back after treatment are thought to not cause damage to the nerves but what makes these cells different to the other cells? What does Lemtrada do to make the new cells "behave" and not attack myelin. Thanks
    Hi luke

    It's kinda technical for my brain , but this article from the NIH explains the action of Alemtuzumab (Lemtrada).

    I think what you're looking for is in the last paragraph under Overview of Pharmacology.

    It says "treatment with Alemtuzumab results in a rapid and dramatic reduction in circulating lymphocytes, with a subsequent preferential reconstitution of the immune system".

    There are different types of lymphocytes: B cells, T cells, NK cells etc.

    And what I can glean from the paragraph, is that when these various lymphocytes start to reconstitute (come back, build up again) after treatment, they don't reconstitute all at once. And they come back in a different order (with B cells first, then CD8+ CD4+ T-lymphocyte cells, etc.)

    So, according to the article, it's this alteration (change-up) of the immune system from Alemtuzumab that is responsible for the improved long-term outcomes for MS patients.

    See what you think of the last paragraph under Overview of Pharmacology.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386803/
    PPMS for 26 years (dx 1998)
    ~ Worrying will not take away tomorrow's troubles ~ But it will take away today's peace. ~

    Comment


      #3
      it is kind of far in the future, especially if you want answers now, but there is going to be a conference in July. Here is a link that will give you some info http://www.msworld.org/forum/showthr...uly-13-17-2015
      hunterd/HuntOP/Dave
      volunteer
      MS World
      hunterd@msworld.org
      PPMS DX 2001

      "ADAPT AND OVERCOME" - MY COUSIN

      Comment

      Working...
      X