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Masitinib Delays Disability Progression in PPMS, Non-active SPMS

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    Masitinib Delays Disability Progression in PPMS, Non-active SPMS

    Mastinab is an oral medication, and it is not a typical immunosupressant, which sounds good to me.

    From the article:


    ~ “These results are the start of a possible revolution in the treatment of multiple sclerosis, as it is the first time a treatment has shown efficacy in both progressive forms of this [disease],” Patrick Vermersch, MD, PhD, the trial’s main coordinator, said in a press release.

    ~ Masitinib (formerly known as AB1010) is an oral, selective tyrosine kinase inhibitor that works by blocking the activity of mast cells, microglia, and macrophages — immune cells people are born with that are believed to play important roles in progressive MS. By suppressing these cells, the therapy is expected to limit neurodegeneration in progressive forms of the disease.

    ~ In conclusion, the trial’s results showed that the low dose of masitinib had a sustained and significant benefit in disability progression in a broad population of progressive MS patients over two years, suggesting that the therapy “may provide a new treatment option for PPMS and non-active SPMS,” Vermersch said.

    The researcher also noted that masitinib’s safety profile “is suitable for long-term administration.”

    In AB Science’s release, Vermersch noted: “Masitinib can be administered on a long-term basis as it is not an immunosuppressive treatment, which is particularly important in patients who are to receive long-term treatment and who, for some, have already an immune system weakened by previous treatments or because of their age.”

    https://multiplesclerosisnewstoday.c...02-study-show/
    PPMS for 22 years (dx 1998)
    ~ Worrying will not take away tomorrow's troubles ~ But it will take away today's peace. ~

    #2
    Thanks KoKo! I'll be keeping my eye on this one. A first for PPMS and non-active SP-

    “These results are the start of a possible revolution in the treatment of multiple sclerosis, as it is the first time a treatment has shown efficacy in both progressive forms of this [disease],” Patrick Vermersch, MD, PhD, the trial’s main coordinator"
    1st sx '89 Dx '99 w/RRMS - SP since 2010
    Administrator Message Boards/Moderator

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      #3
      Yes Thank you for your research KoKo and for keeping us informed
      It was one agains't 2.5million toughest one we ever fought.

      Comment


        #4
        The Press Release has some interesting info too.

        "The relapsing-remitting form characterized by relapses of the disease. During these relapses, patients experience the onset of new symptoms or the worsening of symptoms already present. These flare-ups are usually followed by recovery periods of varying length, after which some symptoms may persist. The relapsing-remitting forms of multiple sclerosis are mostly associated with dysfunctions of adaptive immunity2 (B cells and T cells).

        The progressive form, characterized by a constant and regular worsening of the symptoms of the disease, without a distinct relapse or period of recovery. The rate of onset of severe, disabling, and irreversible disability is much higher in the progressive forms of the disease than in the relapsing remitting forms. In progressive multiple sclerosis, innate3 immune cells such as macrophages, microglia or mast cells have been shown to probably play a major role."

        https://www.globenewswire.com/news-r...onference.html
        PPMS for 22 years (dx 1998)
        ~ Worrying will not take away tomorrow's troubles ~ But it will take away today's peace. ~

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