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age and effectiveness of DMT use

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    age and effectiveness of DMT use

    NIH analysis finds,

    "after age 53, the model suggests that there is no predicted
    benefit to receiving immunomodulatory DMTs for the average MS patient."

    https://www.ncbi.nlm.nih.gov/pmc/art...r-08-00577.pdf

    #2
    Hello. That is quite a report. I myself am grateful for the first chance at a DMT at age 58 when Ocrevus was finally approved here in Canada for PPMS over three years ago.
    However Iíll never know what my progression would have been like if I hadnít have taken it. I felt like I was failing quicker before vs after. That could have been natural as well. If DMTís were the answer then there wouldnít be so many of them
    There would be only one
    Thanks
    It was one agains't 2.5million toughest one we ever fought.

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      #3
      Thanks for posting. I personally am awaiting the Rocky Mountain MS Center's study on age and DMTs.

      I think it is also important that readers look at the bottom of page 10. They are not recommending that all patients stop at 54, but it needs to be reviewed on a personal basis with each clinician. If on a DMT and older, please don't stop taking without discussing with your neuro.

      I personally am hoping the the Rocky Mountain Study says it is safe for me to stop!
      Kathy
      DX 01/06, currently on Tysabri

      Comment


        #4
        Originally posted by caldred View Post
        NIH analysis finds,

        "after age 53, the model suggests that there is no predicted
        benefit to receiving immunomodulatory DMTs for the average MS patient."

        https://www.ncbi.nlm.nih.gov/pmc/art...r-08-00577.pdf
        Although I don't imagine that's accurate for everyone, it seems pretty correct for me. I suspect that my last flare was in 2014, at age 52. By 2015 and 2016, I was noticing considerable, consistent decline and I suspect that I had transitioned to SPMS and my Copaxone was no longer effective.

        I began conversations with my MS Specialist about going off and finally quit Copaxone in July of this year, at the age of 58. I think she usually waits a little longer to take patients off DMTs but I had her blessing. MRIs in 2018 and 2020 helped her to make the decision; more follow up ones will likely be needed to confirm no additional new lesions in the future.

        Diet and lifestyle changes in 2018 halted my decline and I'm fairly stable now. I wish that I would have made those changes years ago.
        ~ Faith
        MSWorld Volunteer -- Moderator since JUN2012
        (now a Mimibug)

        Symptoms began in JAN02
        - Dx with RRMS in OCT03, following 21 months of limbo, ruling out lots of other dx, and some "probable stroke" and "probable CNS" dx for awhile.
        - In 2008, I was back in limbo briefly, then re-dx w/ MS: JUL08
        .

        - Betaseron NOV03-AUG08; Copaxone20 SEPT08-APR15; Copaxone40 APR15-present
        - Began receiving SSDI / LTD NOV08. Not employed. I volunteer in my church and community.

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