The paradigm-shifting evidence of the link between MS and EBV does not exist in isolation. In fact, the relationship has been suspected for more than 40 years, and evidence therein has been accumulating over the past 2 decades.
N JANUARY 2022, Bjornevik and colleagues published the results of a 20-year prospective seroepidemiologic study on the relationship between Epstein-Barr virus (EBV) and multiple sclerosis (MS) in which investigators observed an enormous increase in the risk of MS after EBV infection. They concluded that EBV is the leading cause of MS.1 The study included clinical and serologic data collected from a large cohort of military personnel within the US Department of Defense, and its novel design explored and refuted possible alternative explanations of the association, including reverse causation and confounding. The magnitude of the observed effect, a 32-fold increase in MS risk after EBV infection, is so large to be comparable with that of lung cancer and smoking.
Full article: https://www.neurologylive.com/view/t...iple-sclerosis
N JANUARY 2022, Bjornevik and colleagues published the results of a 20-year prospective seroepidemiologic study on the relationship between Epstein-Barr virus (EBV) and multiple sclerosis (MS) in which investigators observed an enormous increase in the risk of MS after EBV infection. They concluded that EBV is the leading cause of MS.1 The study included clinical and serologic data collected from a large cohort of military personnel within the US Department of Defense, and its novel design explored and refuted possible alternative explanations of the association, including reverse causation and confounding. The magnitude of the observed effect, a 32-fold increase in MS risk after EBV infection, is so large to be comparable with that of lung cancer and smoking.
Full article: https://www.neurologylive.com/view/t...iple-sclerosis