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    #1

    JC antibody test

    I use an HMO so I have my labwork done at LabCorp. I have again tested negative for the presence of JCV DNA. There is no reference range posted or any indication of titer/statistical noise, etc., also it states that the test is not FDA approved and was developed in-house.

    I've noticed that the Quest STRATIFY test is FDA approved and they will automatically (I think) give you a titer, I've also heard that Biogen will pay for it? Do you think I should be happy with the LC result or investigate getting the Quest test? As always, thanks for your time.
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    #2
    I recently had a JCV test done through the Cancer Center where I get my infusions. I was still negative. My MS Specialist refused the test. Apparently there are different tests for the virus.

    Personally...I like the Cancer Center doing the tests. But, I am headed to Quest next week with my free blood test paperwork.

    For me...I am having both tests done. Different test...it will be interesting to see if the result remains the same.
    Katie
    "Yep, I have MS, and it does have Me!"
    "My MS is a Journey for One."
    Dx: 1999 DMDS: Avonex, Copaxone, Rebif, currently on Tysabri

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      #3
      I have been told that when you are negative you do not get a titer #. It means you are .2 or less, only when you get higher than .2 do they give you a #. I have had #s of .24,.28 and .23. I do not know which was from the stratify study and the others were in house from the RMmsC-which is where I go

      I guess you could ask to be part of the stratify study I was asked to participate.

      Hope this helps
      Linda

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        #4
        I am actually traveling 132 miles one way for my JC virus test tomorrow. If you have it done by Quest diagnostics there is no cost to you; Biogen does pay. This is my 3rd or 4th test at Quest.

        I recently called Quest HQ, and they said if your neurologist writes "JC virus titer with index", they will provide your titer number even if you are negative. I'll let you know if it works!

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          #5
          I got my JCV antibody test results back. I'm still negative but this time they gave me my titer number. I was .11. I guess anything under .20 is considered negative. But what exactly does it mean to be .11? Do I have some JCV in me?? Why is .20 the cut off point?

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            #6
            Hi Remy,

            I am very interested in these titers myself! I am also trying to get pregnant, and I tested for CMV virus as well. I got negative last year, so I had to choose negative sperm donors. JC and CMV are both common herpes viruses. I got updated STD tests negative for everything, with CMV titer at .30. .30 is the cutoff for being negative. I know for some of these tests there is a threshold to account for statistical fluctuation.

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              #7
              I hope everyone's titres stay low.

              Dyin,

              I hope you succeed and that all goes well with your pregnancy attempt.

              If you haven't yet, you might want to look at the research about artificial reproductive technology and ms. I can't assess risks and benefits for someone else, and I don't know exactly what you're trying, but speaking generally, it isn't good news. Here is one research abstract from PubMed.

              Clin Immunol. 2013 Nov;149(2):219-24. doi: 10.1016/j.clim.2013.02.001. Epub 2013 Feb 15.
              Artificial reproductive techniques in multiple sclerosis.
              Hellwig K1, Correale J.
              Author information
              Abstract
              Fertility does not seem to be impaired to a larger extent in women with MS. However, infertility and MS might just come coincidentally together and, therefore, MS patients might undergo assisted reproductive treatment (ART). Thus, during the last years different studies evaluating the effects of ART on MS relapses have been published. All of them reported an increase in annualized relapse rate after ART. Furthermore, in a recent study clinical worsening was associated with an increase in MRI activity. Putative mechanisms involved in MS worsening after ART include: temporary interruption of disease modified therapies, stressful events associated with infertility, and immunological changes induced by hormones such as increase in pro-inflammatory cytokines and anti-MOG antibodies, as well as an increase in immune cell migration across the blood-brain-barrier. Overall, neurologists should be aware of this risk and discuss the pros and cons of the procedures with MS patients.
              Copyright © 2013 Elsevier Inc. All rights reserved.

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                #8
                Hi Pipes,

                Thank you for posting that, all I was aware of was the PRIMS study that showed a reduction in disease activity in the second and third trimester. I am doing TDI (ordered my material today) so it mirrors a natural pregnancy attempt. All I am going to use is a trigger shot (generic ovidrel) in order to better time the ovulation. I wish I could ask if the HCG is ok to use but my neuro doesn't support the pregnancy attempt and I had to go doctor shopping for a fertility clinic, so the new place doesn't know what's going on.

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                  #9
                  http://www.medpagetoday.com/MeetingCoverage/AAN/32411

                  http://ms.about.com/b/2011/08/09/tys...-pregnancy.htm (comments section-women opting to take Ty all throughout pregnancy).

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