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    Anti-Lingo

    I am not even sure if this is the proper term. I hear bits about a new sort of potential treatment for MS called, "anti-lingo" or "anti-lingua" Do any of you know about this new drug or family of drugs?

    #2
    anti-lingo-1

    Biogen's remyelination drug that is still in development.


    Anti-LINGO: LINGO-1 itself is a protein in the central nervous system whose role is to halt myelination and prevent the survival of neurons. The cells making up all organs in the body receive such "instructions" regarding when to grow and when to cease growing. Without these sorts of cellular "checks and balances," tissues could grow without restraint, as seen in some malignancies. Anti-LINGO-1 (BIIB033) is an agent with potential remyelinative properties, after animal studies showed that it blocks this protein responsible for stopping the growth of myelin. It was sho-wn to promote spinal cord remyelination and axonal integrity in the animal model of MS (EAE).

    The first trials of experimental anti-LINGO to stimulate myelin repair - human Phase I trials66, involving 64 healthy adult volunteers and 42 people with relapsing or secondary-progressive MS - have been completed. In these trials, intravenous doses of anti-LINGO were well tolerated, and there were no serious adverse events; headache was the most frequent adverse event reported. The authors concluded that the results support advancing this myelin repair strategy into a Phase II clinical trial. The first Phase II trial of anti-LINGO launched in 2013,67 recruiting patients with newly-diagnosed MS involving the visual pathways (optic neuritis) to evaluate its effect on remyelination.

    A second, larger Phase II trial68 looking at this drug in combination with Avonex will recruit approximately 400 patients and examine the degree to which patients have an improvement in disability with anti-LINGO. Since this agent does not reduce relapses or prevent new MRI lesions, further studies with anti-LINGO, and other potential remyelination therapies, will need to utilize new endpoints such as this to prove efficacy. This includes measurements of recovery or improvement on physical, visual, cognitive, and other functional assessments of the effects of MS.

    For a detailed review of the science behind anti-LINGO-1, please see the article in CNS Drugs, "Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to Clinic," Mi et al, 2013.69


    http://www.biogenidec.com/Files/File...NAL-7Mar13.pdf

    http://www.neurology.org/content/82/...plement/P3.154

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      #3
      Thank you, Marco, for the thoughtful reply. This sounds like a potential game changer. I have heard that more times than I can count in the 26 years since diagnosis. Even so, I remain ever hopeful.

      Comment


        #4
        Phase 1 Results Reported for Anti-LINGO-1 Remyelination Agent

        Hopefully this will get bumped to the top.

        BIIB033, a monoclonal antibody targeting the LINGO-1 remyelination signaling block, passes phase 1 safety tests


        Full story here:
        http://tinyurl.com/pn4m77z

        I left in love, in laughter, and in truth, and wherever truth, love and laughter abide, I am there in spirit.

        Bill Hicks

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          #5
          Thanks Marco !
          Think I read-heading into Phase III, ready for us 2016 I want it NOW I am so hoping/praying it helps me and all of us msers
          Linda

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            #6
            Anti lingo

            I have a good feeling about this one. I offered myself as a guinea pig for it to my neurologist, but they weren't asked to take part in the current trials. It's a source of hope, and really 2016 is right around the corner! If it works, we won't have to wait forever.

            Comment


              #7
              I can only hoped that the trials will include 'progressive ' forms of MS. I am so sick and tired of trials 'excluding' progressive MS. I am PPMS and I feel like the meds are always targeting RRMS. Like PPMS and SPMS are stepchildren. I don't like being an outsider!

              **edited by moderator in compliance with guideline 4. It reads: Use of profanity/cursing/pornographic/sexual references in any language is not permitted. Disguised profanity is also prohibited. Note: Disguised Profanity includes but it not limited to adding symbols such as “*” in place of letters in the wording.

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                #8
                JerryD- When I read your post my heart goes out to you. I am RRMS so I can only imagine how frustrating it is for you. Hopefully meds for PPMS will come soon.
                God Bless Us All

                Comment


                  #9
                  Thanks REG. I feel that being the 'stepchild' is almost as bad as being 'abandoned'. Of course, ALL of us MSers have a 'tough row to hoe'! So thanks for your empathy. But I don't want to dismiss the misery of all of the other MSers out there. MS sucks for us all !
                  I think that there is something on the horizon but it seems to be 'hit or miss' as far as positive result for everyone. I read that md 1003 showed mixed results in the trials recently completed in France. I'm pulling for md1003 even if it is a partial treatment !

                  Comment


                    #10
                    I have just found out about this lingo-1.. I'm a little behind to say the least. I feel like this could be a really great thing and makes me feel like doing back flips! I'm trying not to get to excited about it though there has to be SOMETHING wrong with it right?

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                      #11
                      Yeah... you just found out about it ! And it is getting almost no 'press' ! 'If a tree falls in the woods ...' It is very quiet on the Anti-Lingo front ! What's happening ?

                      Comment


                        #12
                        Jerry,

                        Here is a link to some information on Anti-Lingo and another drug they've started using with mice.

                        http://www.medpagetoday.com/clinical...clerosis/53839

                        From what I've read, Anti-Lingo appears to have good and bad associated with it, and is a ways out. Of course, the mice drug is just in the early stages.

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