I am not even sure if this is the proper term. I hear bits about a new sort of potential treatment for MS called, "anti-lingo" or "anti-lingua" Do any of you know about this new drug or family of drugs?
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Anti-Lingo
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anti-lingo-1
Biogen's remyelination drug that is still in development.
Anti-LINGO: LINGO-1 itself is a protein in the central nervous system whose role is to halt myelination and prevent the survival of neurons. The cells making up all organs in the body receive such "instructions" regarding when to grow and when to cease growing. Without these sorts of cellular "checks and balances," tissues could grow without restraint, as seen in some malignancies. Anti-LINGO-1 (BIIB033) is an agent with potential remyelinative properties, after animal studies showed that it blocks this protein responsible for stopping the growth of myelin. It was sho-wn to promote spinal cord remyelination and axonal integrity in the animal model of MS (EAE).
The first trials of experimental anti-LINGO to stimulate myelin repair - human Phase I trials66, involving 64 healthy adult volunteers and 42 people with relapsing or secondary-progressive MS - have been completed. In these trials, intravenous doses of anti-LINGO were well tolerated, and there were no serious adverse events; headache was the most frequent adverse event reported. The authors concluded that the results support advancing this myelin repair strategy into a Phase II clinical trial. The first Phase II trial of anti-LINGO launched in 2013,67 recruiting patients with newly-diagnosed MS involving the visual pathways (optic neuritis) to evaluate its effect on remyelination.
A second, larger Phase II trial68 looking at this drug in combination with Avonex will recruit approximately 400 patients and examine the degree to which patients have an improvement in disability with anti-LINGO. Since this agent does not reduce relapses or prevent new MRI lesions, further studies with anti-LINGO, and other potential remyelination therapies, will need to utilize new endpoints such as this to prove efficacy. This includes measurements of recovery or improvement on physical, visual, cognitive, and other functional assessments of the effects of MS.
For a detailed review of the science behind anti-LINGO-1, please see the article in CNS Drugs, "Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to Clinic," Mi et al, 2013.69
http://www.biogenidec.com/Files/File...NAL-7Mar13.pdf
http://www.neurology.org/content/82/...plement/P3.154
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Phase 1 Results Reported for Anti-LINGO-1 Remyelination Agent
Hopefully this will get bumped to the top.
BIIB033, a monoclonal antibody targeting the LINGO-1 remyelination signaling block, passes phase 1 safety tests
Full story here:
http://tinyurl.com/pn4m77z
I left in love, in laughter, and in truth, and wherever truth, love and laughter abide, I am there in spirit.
Bill Hicks
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I can only hoped that the trials will include 'progressive ' forms of MS. I am so sick and tired of trials 'excluding' progressive MS. I am PPMS and I feel like the meds are always targeting RRMS. Like PPMS and SPMS are stepchildren. I don't like being an outsider!
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Thanks REG. I feel that being the 'stepchild' is almost as bad as being 'abandoned'. Of course, ALL of us MSers have a 'tough row to hoe'! So thanks for your empathy. But I don't want to dismiss the misery of all of the other MSers out there. MS sucks for us all !
I think that there is something on the horizon but it seems to be 'hit or miss' as far as positive result for everyone. I read that md 1003 showed mixed results in the trials recently completed in France. I'm pulling for md1003 even if it is a partial treatment !
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Jerry,
Here is a link to some information on Anti-Lingo and another drug they've started using with mice.
http://www.medpagetoday.com/clinical...clerosis/53839
From what I've read, Anti-Lingo appears to have good and bad associated with it, and is a ways out. Of course, the mice drug is just in the early stages.
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