A 3 month washout period is too long according to yet another study; a fact to consider when stopping Tysabri to begin Gilenya.
The study below looked at serum concentrations and found the lower the concentration of Tysabri the more likely MS will rebound. The longer you wait after stopping Ty the lower will be your concentration of TY and the greater risk of disease activity, according to this study.
Gilenya takes about two months to become effective. Waiting 3 months after discontinuing Tysabri before starting Gilenya, plus the two months before Gilenya becomes effective allows a considerable window of time for MS to rebound. The lesson from this study and the two linked in the preceding post is clear: begin Gilenya as soon as possible after stopping Tysabri to minimize the opportunity for MS to rebound.
Natalizumab saturation: biomarker for individual treatment holiday after natalizumab withdrawal?
http://www.ncbi.nlm.nih.gov/pubmed/24032536
Missykay, I hope your doctor is paying attention to these recently published studies. If not, talk to him about them by printing the abstracts and taking to your next appointment. I'm sure he will be happy to discuss these concerns. Best to you.
The study below looked at serum concentrations and found the lower the concentration of Tysabri the more likely MS will rebound. The longer you wait after stopping Ty the lower will be your concentration of TY and the greater risk of disease activity, according to this study.
Gilenya takes about two months to become effective. Waiting 3 months after discontinuing Tysabri before starting Gilenya, plus the two months before Gilenya becomes effective allows a considerable window of time for MS to rebound. The lesson from this study and the two linked in the preceding post is clear: begin Gilenya as soon as possible after stopping Tysabri to minimize the opportunity for MS to rebound.
Natalizumab saturation: biomarker for individual treatment holiday after natalizumab withdrawal?
http://www.ncbi.nlm.nih.gov/pubmed/24032536
Missykay, I hope your doctor is paying attention to these recently published studies. If not, talk to him about them by printing the abstracts and taking to your next appointment. I'm sure he will be happy to discuss these concerns. Best to you.
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