Few months ago I was asked to get x rays from my lungs, well not really asked, I had to. I declined it and that was that. So I started searching and found an article about TBC and that we are at a bigger risk. I emailed my doctor which he totally ignored.
The latest article I can find about this is this one:
http://informahealthcare.com/doi/abs...75.2014.962517
Than there was another article of a women who passed away after using Tysabri for 5 years. They couldn't find any sign of PML in her autopsy but apparently her cause of death was Creutzfeldt-Jakob disease. They end the article with:
For me personally this makes me mad as I feel they should tell us every bit of information they have. Especially the TBC thing seems to be a bit worrying.
Any opinions on this?
The latest article I can find about this is this one:
http://informahealthcare.com/doi/abs...75.2014.962517
Tuberculosis continues to be a serious health problem worldwide. The disease continues to be underdiagnosed and not properly treated. In conditions that affect the immune system, such as multiple sclerosis (MS), latent tuberculosis may thrive and reactivate during the use of immunomodulatory and immunosuppressive drugs. Among the best treatment options for patients with latent or active tuberculosis who have MS are IFN-β, glatiramer acetate and mitoxantrone. Drugs leading to a reduced number and/or function of lymphocytes should be avoided or used with caution. Tuberculosis must always be investigated in patients with MS and treated with rigor.
Given the low incidence rate of CJD of 0.1/100,000,6 it is tempting to speculate about whether the patient's primary disease or the long-term treatment with natalizumab predisposed her to develop this particular condition. However, the absence of reports on the occurrence of sCJD in patients with MS, especially those on natalizumab, and no clear pathophysiologic links make a chance association most likely.
Any opinions on this?
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