For three years I have had horrible edema in my hands, wrists, feet, ankles, and legs. This started 6 weeks after starting Copaxone. I have had to go to the ER three times whereby the only thing that helped was Solumedrol. I have made 5 trips to the Mayo Clinic whereby no diagnosis was made. Recently I went to Vanderbilt Medical Center in Nashville where a rare form of arthritis was diagnosed---RS3PE. Speculation is that Copaxone triggered something that set this into motion. Has anyone else had anything similar happen to them from taking Copaxone?