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Initial report from TISCH re stem cell trial - Very promising

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    Initial report from TISCH re stem cell trial - Very promising

    TISCH MS RESEARCH CENTER OF NEW YORK REPORTS EARLY IMPROVEMENT IN STEM CELL TRIAL
    April 23, 2015 - TISCH MS RESEARCH CENTER OF NEW YORK REPORTS EARLY IMPROVEMENT IN STEM CELL TRIAL

    Interim Results Indicate Positive Efficacy Trends in FDA-Approved Phase I Clinical Stem Cell Trial For Patients with Multiple Sclerosis

    New York, NY - April 23, 2015 - Tisch MS Research Center of New York (Tisch MSRCNY) today announced encouraging preliminary results from its FDA-approved Phase I trial using autologous neural stem cells in the treatment of multiple sclerosis (MS). MS is a chronic autoimmune disease of the central nervous system where the myelin sheath is attacked and neurodegeneration may occur. It affects more than 2.3 million people worldwide. The significant results were selected for presentation during the Multiple Sclerosis Highlights in the Field session at the 67th American Academy of Neurology (AAN) Annual Meeting in Washington, D.C.

    Tisch MSRCNY research showed that in the interim analysis, six of nine patients are exhibiting increased motor strength, improved bladder function and an enhanced quality of life. Importantly, the treatments are well tolerated and thus far no serious adverse events were reported.

    “This preliminary data is encouraging because in addition to helping establish safety and tolerability, the trial is yielding some positive therapeutic results even at this early stage,” said Dr. Saud A. Sadiq, Chief Research Scientist at Tisch MSRCNY and the study’s principal investigator. He cautioned however, that these results are an interim analysis and definitive conclusions will only be made upon completion of the trial.

    The study investigates a pioneering regenerative strategy using stem cells harvested from the patient’s own bone marrow. These stem cells are injected intrathecally (into the cerebrospinal fluid surrounding the spinal cord) in 20 participants who meet the inclusion criteria for the trial. This is an open label safety and tolerability study and all activities are conducted at Tisch MS Research Center of New York and affiliated International Multiple Sclerosis Management Practice. The interim analysis reports on the first nine patients that have received at least one treatment of stem cells.

    Study patient Vicky Gill, a married mother of two whose husband, Michael, also has MS, has already experienced the positive benefits of the therapy. “For the past six years, I would fall frequently, had very limited movement in my legs and always walked with my cane. After just two stem cell treatments, I am now gaining sensation and function I thought was totally lost, have not had any recent falls and at times don’t need a cane at all.”

    Trial patients receive three rounds of injections at three month intervals. Safety and efficacy parameters will be evaluated in all patients through regular follow-up visits. Dr. Sadiq plans to continue and complete the Phase I study and if these positive trends continue, move on to a multi-center Phase II efficacy trial.

    For more information on this study visit: www.tischms.org

    Check out the full article below as good charts showing patient's progress.

    Full article here



    http://www.tischms.org/news/april-23...tem-cell-trial
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