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Statins: Potential Future SPMS Treatment

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    Statins: Potential Future SPMS Treatment

    Statins (e.g., atorvastatin, pravastatin, rosuvastatin, simvastatin) are FDA approved for lowering cholesterol levels. A meta-analysis of eight statin treatments trials for Multiple Sclerosis was conducted. Indications for monotherapy and combination therapy with interferons for RRMS was ruled out. Stain monotherapy for CIS was also not recommended.



    Interestingly enough, statins may be beneficial in secondary progressive multiple sclerosis (SPMS). Authors noted a reduction in progression of disability and in brain atrophy in the SPMS study but no impact on relapse rate. The benefit thereof and whether this is due to a direct immunomodulatory and neuroprotective effect warrant further studies.


    http://www.ncbi.nlm.nih.gov/pubmed/25795002




    #2
    Hi Marco,

    I really appreciate the informational articles you post and the help you provide here on MSWorld.

    The article posted concerns me as Statins have become quite dangerous, for many, to use and especially if you have MS.

    A few years ago I was on a Statin. In the year and a half I was on the Statin my cognitive decline was obvious to all and scary, I lost what little strength I had and walking was too much of an effort. I lost my ability to drive as I no longer had the focus to do so. I was becoming lost in familiar places. My fatigue worsened.

    My husband was quite concerned I was developing Alzheimer's, I believed the MS had taken a really bad turn and I was quickly loosing the battle. I had lost my ability to verbalize complete thoughts and in frustration I would cry.

    When my Neurologist heard I was on a Statin and he cringed.

    I was referred for Neuropsych testing and it was there I found out those in the NeuroPsych profession were seeing case after case of clients like me who had also been using a Statin. Everything I was experiencing was due to the side effects of the Statin.

    The Neuropsych informed me my case would be used in a report that would be submitted about the dangers of Statins.

    Approximately 6 months after this the FDA put out warnings on Statins.

    I was taking a very low dose (10mg) of a Statin. I believed it was a needed medication that would benefit my Cholesterol numbers, which it did. Unfortunately, it left me in worse condition than before I started it.

    Within 2 weeks of stopping the Statin my cognitive difficulties improved. It took quite a few months to try and regain my strength and endurance. This process was as frustrating as when I fight to regain my mobility due to MS.

    In my personal opinion Statins are dangerous. I will never, never use one ever again.

    Anyone considering a Statin should discuss this with your Neurologist.
    Diagnosed 1984
    “Lightworkers aren’t here to avoid the darkness…they are here to transform the darkness through the illuminating power of love.” Muses from a mystic

    Comment


      #3
      I am going to ditto what Snoopy said.

      Last year I was hospitalized and was having MS Complications from the drug induced Anemia. My heart was wonky.

      The Cardiologist put me on a Statin, 10mg. As a precaution, even though my cholesterol was normal. My MS Specialist was unaware.

      Within a week, I was barely walking and the pain...bottomline it was the Statin. My Neuro was very upset...he took me off immediately...poor Cardiologist. Sometimes this process can not be reversed once damage is done.

      This study is great...however, please do not take a Statin of any sort without consulting your Neuro, especially those on DMDs, which can make this side effect much more likely.
      Katie
      "Yep, I have MS, and it does have Me!"
      "My MS is a Journey for One."
      Dx: 1999 DMDS: Avonex, Copaxone, Rebif, currently on Tysabri

      Comment


        #4
        How long did you

        take statins, Snoopy and Katie?

        Comment


          #5
          Originally posted by its2much View Post
          take statins, Snoopy and Katie?
          Only about 10 days...thats all it took. I completely recovered in about a week after being removed from the statin. The effect can happen to anyone, however my Neuro just lost it. And to make it worse...some of the DMDs can make it as much as 10 times more likely to happen, according to my Neuro.
          Katie
          "Yep, I have MS, and it does have Me!"
          "My MS is a Journey for One."
          Dx: 1999 DMDS: Avonex, Copaxone, Rebif, currently on Tysabri

          Comment


            #6
            Approximately a year and a half.

            The effects started much earlier but my PCP blamed my MS and I did not know Statins could do the damage and symptoms I was experiencing.
            Diagnosed 1984
            “Lightworkers aren’t here to avoid the darkness…they are here to transform the darkness through the illuminating power of love.” Muses from a mystic

            Comment


              #7
              I will also ditto what Katie and Snoopy said. I am primary progressive, but I noticed those symptoms also. I was on it for about four months. I was also allergic to them and they would cause my liver enzymes to drop too low.
              hunterd/HuntOP/Dave
              volunteer
              MS World
              hunterd@msworld.org
              PPMS DX 2001

              "ADAPT AND OVERCOME" - MY COUSIN

              Comment


                #8
                I appreciate all that modern medicine has been done to help us, who need help drastically. But I thought the oath starts with "first, Do No Harm". What is the next line? Line up some guinea pigs ?

                Comment

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