Statins (e.g., atorvastatin, pravastatin, rosuvastatin, simvastatin) are FDA approved for lowering cholesterol levels. A meta-analysis of eight statin treatments trials for Multiple Sclerosis was conducted. Indications for monotherapy and combination therapy with interferons for RRMS was ruled out. Stain monotherapy for CIS was also not recommended.
Interestingly enough, statins may be beneficial in secondary progressive multiple sclerosis (SPMS). Authors noted a reduction in progression of disability and in brain atrophy in the SPMS study but no impact on relapse rate. The benefit thereof and whether this is due to a direct immunomodulatory and neuroprotective effect warrant further studies.
http://www.ncbi.nlm.nih.gov/pubmed/25795002
Interestingly enough, statins may be beneficial in secondary progressive multiple sclerosis (SPMS). Authors noted a reduction in progression of disability and in brain atrophy in the SPMS study but no impact on relapse rate. The benefit thereof and whether this is due to a direct immunomodulatory and neuroprotective effect warrant further studies.
http://www.ncbi.nlm.nih.gov/pubmed/25795002
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