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    Understanding some results?

    Hi,
    So I've been going round and round trying to figure out what's going on with my body. Had a spinal tap and just got a couple of the results back online but some things don't have ranges. Anyone know if these are normal? The monocytes seem a little high?
    Thanks,
    Isabell


    Lymphocytes 13 %
    Monocytes 87 %

    #2
    This is VERY abnormal and something you need to talk with your neurologist about. I assume they will contact you soon, if not, contact them.

    Good luck, let us know how it goes, OK?

    Lisa
    Moderation Team
    Disabled RN with MS for 14 years
    SPMS EDSS 7.5 Wheelchair (but a racing one)
    Tysabri

    Comment


      #3
      Well that's not good! Are there certain things this could be caused from? Do these numbers have to do with ms probability?

      I already have an appointment this week to talk with the neurologist.
      Thanks for your thoughts.
      Isabell

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        #4
        Could these value ranges differ because the came out if spinal fluid?
        Isabell

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          #5
          Understanding Lab Results

          I recently had blood work done and my lab included the reference intervals for both monocytes and lymphocytes:

          Monocytes : 4% - 13%

          Lymphocytes: 14% - 46%

          Hope this is of some help to you.

          Comment


            #6
            Originally posted by jessiesmom View Post
            I recently had blood work done and my lab included the reference intervals for both monocytes and lymphocytes:

            Monocytes : 4% - 13%

            Lymphocytes: 14% - 46%

            Hope this is of some help to you.
            Would these ranges be different for a spinal tap?

            Comment


              #7
              Originally posted by MooseR View Post
              Could these value ranges differ because the came out if spinal fluid?
              Isabell
              Yes they could, but there are a variety of factors that could influence the "normal" CSF cell counts. It's important to discuss the results with your doctor, as mentioned by 22cyclist.

              The differential cell count is only a small portion of the results of a spinal fluid analysis so you'll need to discuss the whole picture with your doctor. Most neurologists will be looking most closely at the IgG oligoclonal band results.

              I looked this up on "UpToDate" which is an expensive subscription online medical information source (I have access at work). The "Patient Information" section of the website is free though, and has useful information on many topics, including MS.

              MooseR, I hope you get good answers to your questions soon from your doctor.

              Comment


                #8
                Originally posted by onlyairfare View Post
                Yes they could, but there are a variety of factors that could influence the "normal" CSF cell counts. It's important to discuss the results with your doctor, as mentioned by 22cyclist.

                The differential cell count is only a small portion of the results of a spinal fluid analysis so you'll need to discuss the whole picture with your doctor. Most neurologists will be looking most closely at the IgG oligoclonal band results.

                I looked this up on "UpToDate" which is an expensive subscription online medical information source (I have access at work). The "Patient Information" section of the website is free though, and has useful information on many topics, including MS.

                MooseR, I hope you get good answers to your questions soon from your doctor.
                Thank you for this information. I think it's just so much to take in and I'm overwhelmed. I keep thinking I will get answers this week but I have a feeling it's just going to turn into more tests. Sigh.
                Isabell

                Comment


                  #9
                  Originally posted by MooseR View Post
                  Well that's not good! Are there certain things this could be caused from? Do these numbers have to do with ms probability?
                  Yes of course there are certain things your results could be caused from. But that's a question that gets into differential diagnosis and that's best left to your neurologist and possibly other specialists.

                  If you have hours to google around you can read about cerebrospinal fluid in normal healthy people and in people with MS and other conditions. In normal healthy adults the mix in spinal fluid is about 70% lymphocytes and 30% monocytes.

                  Lymphocytes and monocytes aren't considered in the diagnosis of MS so "probability" of MS isn't a consideration either. And by itself this result isn't diagnostic of anything.

                  With MS no test by itself is diagnostic of MS. The same thing is true of other conditions too. So you really do have to wait for all of your test results to come back and for your doctors to put all of the puzzle pieces together to find out what the big picture shows. Patience is a virtue.

                  Comment


                    #10
                    Originally posted by MSer102 View Post
                    Yes of course there are certain things your results could be caused from. But that's a question that gets into differential diagnosis and that's best left to your neurologist and possibly other specialists.

                    If you have hours to google around you can read about cerebrospinal fluid in normal healthy people and in people with MS and other conditions. In normal healthy adults the mix in spinal fluid is about 70% lymphocytes and 30% monocytes.

                    Lymphocytes and monocytes aren't considered in the diagnosis of MS so "probability" of MS isn't a consideration either. And by itself this result isn't diagnostic of anything.

                    With MS no test by itself is diagnostic of MS. The same thing is true of other conditions too. So you really do have to wait for all of your test results to come back and for your doctors to put all of the puzzle pieces together to find out what the big picture shows. Patience is a virtue.
                    I guess my response was kind of funny....of course it's something haha. I'm not great at patience and I feel like this process is taking far too long. Plus, I can feel that something is not right with my body which makes it all the worse. Thanks for your input.
                    Isabell

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                      #11
                      I spoke to the neurologist this morning and he said that my numbers are fine. Everything that I looked at said my numbers were way off. Ah!
                      Isabell

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                        #12
                        That's where the other specialists come in.

                        You said that your neuro wants you to see an infectious disease specialist to evaluate for a herpes infection affecting your central nervous system. The infectious disease specialist should be able to comment on your lumbar puncture analysis.

                        It would also make sense for you to see a rheumatologist because you have symptoms of Sjogren's syndrome even tho the screening test your neuro ordered was negative.

                        Sjogren's in the central nervous system and MS can be extremely difficult to tell apart. Dry eyes are pretty common but a dry mouth isn't. So neurological signs and symptoms that look like MS take on a different meaning when a dry mouth is involved. It's possible to have both MS and Sjogren's but a rheumatologist will have to make the call about the Sjogren's. The rheumatologist should be able to comment on your lumbar puncture analysis too.

                        Comment


                          #13
                          Well, it is not MS. They don't know what is going on. They did find a gene defect which is rather interesting. They said it was not clinically significant but the fact that they can't find anything else wrong I think makes it significant.
                          Isabell

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